Abstract 17879: Are Lipoproteins Associated With Cognitive Performance?
There is evidence indicating that lipid levels may be associated with cognitive function, particularly among women. We aimed to examine low density lipoprotein (LDL), triglycerides, high density lipoprotein (HDL), and HDL/LDL ratio in relation to cognitive performance, measured with six well-established domains (verbal memory, non-verbal memory, visuospatial, executive function, attention/working memory, and language). Blood profile and neuropsychological assessment were available for a total of 91 adults with MMSE scores ≥ 24 (mean age=68.3 years, 48% female, mean education=13.9 years) attending a neuropsychological evaluation at a Memory Clinic in Prague, Czech Republic. Ordinary least squares regressions were adjusted for age, gender and education. Gender-specific analyses were also estimated. None of the lipoprotein indicators were significantly associated with visuospatial skills, executive function, language and verbal memory. However, high HDL was associated with better attention/working memory (Digit Span Backward; β=0.24; p=.010). Gender-specific analyses suggested that this association was mainly driven by women (β=0.26; p=.047) and was not significant in men (β=0.19; p=.237); high HDL-to-LDL ratio was also significantly related to better attention/working memory in women only (β=0.27; p=.033) and not in men (β=-0.02; p=.892). Although not significant in the entire sample, higher HDL-to-LDL ratio was associated with better non-verbal memory (Rey-Osterrieth Complex Figure Test reproduction) in women (β= 0.22; p=.052) and not men (β=-0.05; p=.705). In summary, we found that HDL and HDL/LDL ratio were related to better attention/working memory and non-verbal memory, mainly among women. This result is especially pertinent given the prominent role of these domains in understanding cognitive aging.
- © 2013 by American Heart Association, Inc.