Abstract 17876: BNP Ratio Can Predict Early Rehospitalization in Patients With Heart Failure
Background: It has been reported that B-type natriuretic peptide (BNP) guided heart failure therapy is effective in clinical practice. However, BNP level is affected by the underlying cardiac disease and it is not well investigated which BNP parameters should be used to manage the patients with heart failure. Thus, in this study, we examined whether BNP ratio (BNP level at discharge / that at admission) were correlated with rehospitalization in the patients with heart failure.
Methods: We enrolled 277 consecutive octogenarian patients with heart failure who were admitted into our hospital from 2009 to 2011. Our patients were divided into the rehospitalization(RH)group who were readmitted within one year and non-RH group. We compared age, gender, the incidence of atrial fibrillation, BNP ratio and oral medication including β blocker, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker (ACE/ARB), aldosterone antagonist, statin, diuretics between the two groups by multivariate analysis.
Results: Multivariate analysis showed BNP ratio was significantly higher in RH group than in non-RH group (0.865±1.191 vs. 0.446±0.516, p=0.009) while the other parameters did not show the significant differences between the two groups. By constructing a receiving operating characteristics curve for BNP ratio, we identified an optimal cut-off value of 0.47 that minimized false positive and negative results (figure), obtaining a sensitivity and specificity of 73.4% and 68.8%, respectively.
Conclusions: BNP ratio can predict rehospitalization within one year in the patients with heart failure. To decrease the incidence of rehospitalization in the patients with heart failure, it is important to manage these patients using BNP ratio-guidance.
- © 2013 by American Heart Association, Inc.