Abstract 17839: Association of Parental Obesity and Diabetes With Circulating Levels of Adipokines in Non-Obese Non-Diabetic Offspring: The Framingham Heart Study
Background: Parental history of obesity and diabetes are key risk factors for the occurrence of these conditions in their offspring. It is unclear if parental history confers greater risk in offspring in part via influences on the circulating levels of adipokines implicated in obesity and diabetes. We hypothesized that non-obese offspring (BMI <25 mg/kg2) of obese parents (BMI ≥ 30 mg/kg2) will have an altered serum adipokine levels when compared to non-obese offspring of non-obese parents: circulating levels of fetuin-A, fatty-acid binding protein 4 (FABP4), retinol binding protein 4 (RBP4), soluble leptin receptor will be higher, whereas levels of leptin and adiponectin will be lower. We also hypothesized that a similar altered circulating adipokines pattern will be seen in non-diabetic children of diabetic parents.
Methods: We evaluated 2034 non-obese, non-diabetic Framingham Third Generation (Gen 3) cohort participants (mean age 40 years, 54% women) with both parents enrolled in the Framingham Offspring (Gen 2) cohort. Parental diabetes was defined as diabetes in either parent anytime over their lifecourse, and obesity was defined as a BMI of ≥30 mg/kg2 occurring before age 60. We compared serum levels of adipokines among Gen 3 participants with affected (defined as a. parental obesity; and b. parental diabetes) versus unaffected parents (in Gen 2) using generalized estimating equations.
Results: 44% of Gen 3 participants had at least one obese parent, whereas parental diabetes was present in 15%. Parental obesity was associated with higher serum levels of FABP4 and soluble leptin receptor, whereas parental history of diabetes was associated with lower mean serum levels of adiponectin but increased RBP4 levels (Table).
Conclusion: In our large, community-based sample of young participants, a parental history of diabetes or obesity was associated with an altered adipokine profile in their non-diabetic non-obese offspring.
- © 2013 by American Heart Association, Inc.