Abstract 17835: Lipid Accumulation Product (LAP) is Associated With Subclinical Vascular Inflammation in Persons Without Metabolic Syndrome
BACKGROUND: Lipid accumulation product (LAP) is a simple indicator that only requires the determination of circulating triglycerides and measurement of waist circumference. It has recently been shown to strongly predict metabolic syndrome (MetS) and its associated risks. However, little is known if LAP will have similar value among those without known MetS. We aimed to investigate whether LAP is related to subclinical vascular inflammation among those with and without MetS.
METHODS: We evaluated 6,457 healthy Brazilian subjects (43±10 years, 79% males) without clinical coronary heart disease between November 2008 and July 2010. LAP (waist-58 х triglycerides [nmol/L]) cutoff point of ≥34.5 was used. C-reactive protein ≥ 3mg/dL was used as a marker for subclinical vascular inflammation.
RESULTS: The prevalence of CRP ≥ 3mg/dL was 31% (n=2,007) and 3,322 (51%) had LAP index ≥ 34.5, (MetS+ 96% vs. MetS- 40%, p<0.001). MetS+ individuals were more likely to have elevated CRP, 38% vs. 29%, (p<0.001) and Individuals with LAP index ≥34.5 had higher CRP (p<0.001). Among individuals without MetS, elevated LAP was 1.75 times more likely to predict an elevated CRP level. Interestingly, no association was seen in the group with MetS. The result of the unadjusted and adjusted regression model is presented in the table below.
CONCLUSIONS: In this cohort of asymptomatic individuals, there is a stronger association between the LAP index and systemic inflammation in persons without metabolic syndrome. It may imply that the LAP index may be a useful tool in predicting subclinical CVD among individuals without metabolic syndrome. Future studies to ascertain the predictive value are important.
- © 2013 by American Heart Association, Inc.