Abstract 17823: Etiology of Gender Differences in Cardiac Troponin I Concentrations
Background: The distribution of circulating cardiac troponin differs in men and women. The etiology of these differences, and their clinical implications, remain unclear.
Methods and Results: Using a novel high-sensitivity assay, we measured circulating cardiac troponin I (hsTnI) in 7272 male and 4097 female participants in a multicultural primary prevention population from 26 countries who had LDL-C < 130 mg/dL, and high-sensitivity C-reactive protein ≥ 2 mg/L (the JUPITER trial). A significantly higher proportion of men (6780/7272, 93%) had hsTnI values at or above the limit of detection of 1.9 ng/L compared to women (3604/4097, 88%, P<0.0001). Median (IQR) hsTnI levels were higher in men [3.9 ng/L (2.3-4.3)] than in women [3.6 ng/L (2.7-5.2); P<0.0001] (Figure). Baseline correlates of natural logarithm transformed hsTnI concentrations were identified through sex-stratified multivariable regression and were similar in men and women (Table). Independently and significantly correlated covariables included age, race, systolic blood pressure, treatment for hypertension, renal function, high-density lipoprotein cholesterol, and apolipoproteins B100 and A-I (Table). The univariate difference in ln(hsTnI) concentrations between women and men (beta= -0.183, SE=0.018, P<0.0001) appeared stronger after adjusting for all the possible confounders identified in the Table (beta = -0.288, SE 0.021, P<0.0001).
Conclusion: The etiology of sex-specific differences in circulating troponin values remains incompletely explained. (NCT00239681)
- © 2013 by American Heart Association, Inc.