Abstract 17748: Statin Therapy, in Addition to Early Treatment Before Clitical Limb Ischemia, is Associated With Better Outcome After Endovascular Therapy for Femoro-popliteal Lesions
Background: In endovascular therapy (EVT) for femoro-popliteal (FP) lesions, we can achieve high initial success rate, but higher restenosis rate is one of the major problems.
Purpose: We investigate the factors associated with restenosis after EVT for FP leions.
Methods: We enrolled 113 consecutive patients with 129 FP. We divided them into restenosis group and non-restenosis group. Restenosis was detected by angiographic or ultrasonic evaluation. We compared, the incidence of diabetes mellitus, hypertension, dyslipidemia, hyperuricemia, smoking, coronary artery disease, cerebrovascular disease, clitical limb ischemia (CLI), chronic total occlusion, and medication including statins, renin-angiotensin system blockers, insulin, and cilostazol between two groups.
Result: We peformed multivariate analysis with parameters whose p value of univariate analysis showed <0.20. Multivariate analysis showed the use of statin was significantly lower (p=0.0088, OR=0.06, 95%CI=0.01-0.50) and CLI lesion was significantly higher (p=0.0233, OR=82.42, 95%CI=1.82-3731.41) in restenosis group than non-restenosis group. Moreover, statin use was associated with better outcome compared to non-statin use in Kaplan-Meier analysis of restenosis-free curve (log rank P=0.0005).
Conclusion: Statin therapy, in addition to early treatment before CLI, can reduce the restenosis rate after EVT for FP lesion.
- © 2013 by American Heart Association, Inc.