Abstract 17684: Preliminary Effects of Renal Sympathetic Denervation With Saline Irrigated Catheter on Systolic Function in Patients With Heart Failure--A Feasibility Report From the Swan-hf Pilot Study
Objectives: To assess the efficacy and safety of renal sympathetic denervation (RSD) using saline irrigated catheter in patients with heart failure.
Background: RSD has been demonstrated to be a safe and effective method for blood pressure control of resistant hypertension. However, the feasibility of RSD for heart failure (HF) is unclear.
Methods: Forty-nine patients with HF were enrolled, and 27 patients were assigned to intervention group treated with RSD while 22 patients were assigned to control group treated with standard pharmacotherapy. Six-minute walk test, LVEF and other echocardiogram parameters were measured at baseline, 3, and 6 months to evaluate cardiac systolic function.
Results: Four patients in intervention group were excluded for anatomical reasons. 21 patients in intervention group and 20 patients in control group were followed up 3 to 6 months. No severe adverse events were observed during follow-up. LVEF in intervention group significantly increased compared with that in control group during 3 months (44.9±8.7 vs 33.5±7.5, p<0.001) and 6 months (46.3±9.4 vs 32.7±7.3, p<0.001) follow-up. SMWD in intervention group significantly improved compared with that in control group (p=0.001 at 3 months; p<0.001 at 6 months). Meanwhile, other echocardiographic parameters including RAD, LVEDD, RVEDD, IVSAM, LVPWMA and FS in intervention group were also significantly improved, while SBP and DBP in intervention group showed no significantly decrease compared with that in control group during 6 months follow-up.
Conclusions: The results suggest that RSD not only improves cardiac systolic function but also reverse myocardial remodeling process in patients with HF.
- © 2013 by American Heart Association, Inc.