Abstract 17678: Prognostic Value of Angina Related Health Status in Women With Suspected Coronary Artery Disease
Background: Angina-related health status as measured by the Seattle Angina Questionnaire (SAQ) has been shown to predict outcomes in patients with coronary artery disease (CAD), but few data are available for women. We sought to investigate the prognostic role of angina health status domains in predicting long-term outcomes in women.
Methods: 1062 females (age 63 ± 12, 76% white, 33% diabetic, 73% hypertensive) with suspected CAD undergoing coronary angiography were followed for 3.5±2.3 years for a primary endpoint of all-cause death and/or myocardial infarction (MI).Three domains of SAQ were assessed: health-related quality of life (HRQOL), physical limitation (PL), and angina frequency (AF), on a scale of 0 to 100. Severity of CAD was measured using the Gensini scoring system. Cox regression was used to examine the association between QOL score and death/MI.
Results: 55% of women had >50% stenosis in at least one major epicardial artery.193 patients (18%) suffered death/MI during follow-up. HRQOL was independently associated with the severity of CAD after adjustment for all conventional risk factors and history of depression (p=0.02).In a model adjusting for age, traditional CAD risk factors, comorbidities, history of depression, ejection fraction, Gensini severity score, acute MI, aspirin and statin use, HRQL was an independent predictor of death/MI (HR =0.97, P=0.019) indicating 3% increase in risk of death/MI with each 5 point increment in the score. Similarly PL (HR: 0.995, p=0.045) and AF (HR: 0.994, p=0.046) independently predicted risk of death/MI in models adjusted for variables stated above.
Conclusion: In women with CAD, HRQOL and other angina-related health status domains are significantly associated with the severity of CAD and predict long-term outcomes independent of other cardiovascular risk factors.
- © 2013 by American Heart Association, Inc.