Abstract 17662: Association of Lipid Core Plaque as Detected by Coronary Near-infrared Spectroscopy With Short- and Long-term Outcomes After Cardiac Catheterization
Background: We examined the association of lipid core plaque (LCP) as detected by intracoronary near-infrared spectroscopy (NIRS) with short- and long-term clinical outcomes after coronary angiography and percutaneous coronary intervention (PCI).
Methods: Between 2009 and 2012 coronary NIRS was performed in 185 coronary arteries in 162 patients who underwent clinically-indicated cardiac catheterization. PCI was performed in 132 coronary arteries. LCP was defined as at least 2 contiguous yellow blocks on the block chemogram. The association of LCP with short and long-term outcomes was evaluated. Short term major adverse cardiac events (MACE) included peri-procedural myocardial infarction (MI), stroke, death, stent thrombosis and no reflow. Long-term MACE included all-cause mortality, stroke, re-hospitalization for acute coronary syndrome (ACS), MI, target vessel revascularization and target lesion revascularization.
Results: Mean age was 62 ± 8 years and most patients (98%) were men. Most patients presented with an acute coronary syndrome (45%) or stable angina (43%). LCP was present in 96 (52%) of the imaged vessels. The mean lipid core burden index was 90 ± 63. Median follow-up was 33 ± 11 months. Patients with and without LCP outside the PCI target lesion had similar short-term (4.3% vs 3.8%%, p=1.0) and long-term (8.7% vs. 6%, p=0.65) MACE. Among patients who did not undergo PCI, LCP was present in 22 of 53 (42%) imaged vessels. The incidence of short-term (0% vs 2%, p = 1.0) and long-term (7% vs 10%, p=0.85) MACE was similar in those patients with and without LCP who did not undergo PCI.
Conclusion: We found no difference in short- or long-term cardiovascular outcomes between patients with and without LCP outside the PCI target segments.
- © 2013 by American Heart Association, Inc.