Abstract 17581: High Systemic Lupus Erythematosus Disease Activity Index is the Predictor for Cardiorenal Syndrome in Systemic Lupus Erythematosus Patients
Objective: To investigate the prevalence of cardiorenal syndrome in patients with systemic lupus erythematosus (SLE) and estimate the associated risk factors for cardiorenal syndrome.
Methods: This cross-sectional study was conducted in 141 SLE patients treated in our hospital. The demographic data and the clinical data including SLE duration, therapeutic regimen, SLE Disease Activity Index (SLEDAI), and associated biochemical parameters were analyzed. Clinical presentation and estimated glomerular filtration rate (eGFR) and cardiovascular ultrasound were used for detecting and analyzing the cardiorenal syndrome. Cardiorenal syndrome was defined as eGFR<60 and systolic or diastolic heart failure or established cardiovascular disease.
Results: Thirty-three cases of cardiorenal syndrome were found in the 141 SLE cases (23.4%). The prevalence of hypertension differed significantly between patients with and those without cardiorenal syndrome (43.3% vs 18.0%. p<0.01). Compared to those without cardiorenal syndrome, patients with cardiorenal syndrome had older (51.4±14.7 vs 41.2±13.1 year-old, P<0.01), Higher SLEDAI score (11.0±6.2 vs 8.3±5.6, p=0.03). Logistic regression analysis showed that age (p=0.002), hypertension (p=0.001), SLEDAI score (p=0.04), serum C3 (p=0.03) were the risk factors for cardiorenal syndrome in SLE patients.
Conclusions: SLE is associated with a high risk of cardiorenal syndrome which increases with aging and with hypertension. High SLEDAI score is not only parameter of disease activity but also the predictor for cardiorenal syndrome in SLE patients.
- © 2013 by American Heart Association, Inc.