Abstract 17563: Rescan Reproducibility of Quantitative Coronary Plaque Burden From Low Radiation Dose High-pitch Coronary Ct Angiography
Introduction: Coronary Computed Tomography angiography (CTA) can characterize coronary atherosclerotic plaque components as calcified and non-calcified. Quantitative measurements of coronary plaque burden by CTA might play a role in serial studies to determine disease progression or response to medical therapies. Rescan reproducibility of such quantitative measurements from low-radiation dose CTA has not been previously assessed.
Purpose: To evaluate the interscan and interobserver variability for coronary plaque volume assessment using low radiation dose high-pitch spiral acquisition coronary CT angiography (CTA).
Methods: Two experienced observers independently evaluated coronary CTA datasets from 50 consecutive patients undergoing two 128-slice dual source CT scans within 12 days. Mean (±SD) estimated radiation exposure was 1.5 mSv ±0.2 mSv per scan. Observers evaluated coronary plaque volumes using validated software (AutoPlaq) on a per plaque level and per patient level, and reproducibility was assessed using Bland-Altman analyses, spearman′s rho correlation and paired t-test.
Results: There were no significant mean differences in interscan or interobserver non-calcified plaque volumes, or in patient non-calcified or total plaque volumes (Table).
Conclusion: Low radiation dose high-pitch coronary CTA, with semi-automated quantitative measurements, allow reproducible characterization and measurement of coronary atherosclerotic plaque burden from serial scans.
- © 2013 by American Heart Association, Inc.