Abstract 17529: Prehypertension and Hypertension Are Associated With Non-Alcoholic Fatty Liver Disease Independent of Traditional Cardiovascular Disease Risk Factors
Introduction: Earlier studies have demonstrated a relationship between hypertension and non-alcoholic fatty liver disease (NAFLD). However, little is known about the relationship between prehypertension (PHT) and NAFLD. From a Brazilian cohort of healthy middle-aged men and women we assessed the relationship between blood pressure (BP) groups including prehypertension and NAFLD.
Methods: We classified those with systolic BP (SBP) < 120mmHg and diastolic BP (DBP) < 80mmHg and not on any antihypertensive medication were categorized as optimal BP. Early stage PHT was defined as SBP 120-129mmHg or DBP 80-84mmHg in the untreated while late stage PHT was categorized as SBP 130-139mmHg or DBP 85-89mmHg in the untreated. Those with hypertension had SBP ≥ 140mmHg, DBP ≥ 90mmHg or were on medication for hypertension. Persons with alcohol consumption >20g/d were excluded and NAFLD was determined using ultrasound.
Results: Among the study population of 6,385 healthy adults, the prevalence of NAFLD was 36.2%. The prevalence of NAFLD among those with optimal BP, early stage PHT, late stage PHT and hypertension was 17.1%, 35.9%, 48.4% and 60.9%. In unadjusted analysis, both early and late PHT were associated with elevated risk of NAFLD (early stage PHT OR = 2.7 95% CI 2.4, 3.1; late stage PHT OR=4.5 95% CI 3.7, 5.6). This significant association persisted even after controlling for age, sex, and metabolic syndrome or individual metabolic risk factors.
Conclusion: In this population, prehypertension is independently associated with the presence of NAFLD. Further studies are required to determine the temporal relationship between prehypertension, hypertension and NAFLD.
- © 2013 by American Heart Association, Inc.