Abstract 17490: Coenzyme Q10 Levels Are Associated With Occurrence of Cardiogenic Shock and In-hospital Death in Patients Admitted to Coronary Care Unit
Background: Coenzyme Q10 (CoQ10) is a mitochondrial coenzyme which is essential for the production of Adenosine triphosphate (ATP). CoQ10 has a potential role for prevention and treatment of heart failure by improving cellular bioenergetics. In addition it has an antioxidant, a free radical scavenging and a vasodilator effect which may be helpful in these conditions. However, clinical significance of measuring serum CoQ10 levels in patients admitted coronary care unit (CCU) remains unclear.
Methods: We enrolled consecutive 276 patients who admitted to the CCU and 54 age- and gender-matched healthy controls. Serum CoQ10 levels were measured after an overnight fast within 24 hours from admission. We examined the associations of serum CoQ10 levels with patient characteristics and occurrence of in-hospital death.
Results: In 276 patients, 146 patients showed acute decompensated heart failure. There were 8 In-hospital deaths. CoQ10 levels were significantly lower in patients admitted to CCU than in healthy controls (0.54±0.34 vs. 0.90±0.31 mg/L, p<0.0001). In patients admitted CCU, CoQ10 levels were negatively associated with age, serum creatinine levels and C reactive protein levels, and positively with high density cholesterol levles (all p<0.05). Low CoQ10 levels also correlated with low diastolic blood pressure, and patients who showed cardiogenic shock (n=5) on admission had lower CoQ10 levels than others (Figure). In 187 male patients, patients with in-hospital death showed lower CoQ10 levels than the survivors (0.39±0.09 vs. 0.56±0.38 mg/L, p=0.02).
Conclusion: Low CoQ10 levels are significantly associated with various risks of cardiovascular disease, including renal dysfunction, inflammation, lipid disorder and hypotension. Low CoQ10 levels correlates with the risk of cardiogenic shock and in-hospital death in patients admitted to CCU, suggesting that measuring CoQ10 levels is useful to detect the high risk patients in CCU.
- © 2013 by American Heart Association, Inc.