Abstract 17468: Up-regulation of Bone Marrow and Splenic Activity After Acute Coronary Syndrome: Close Relationship With Arterial Inflammation and CRP
Introduction: Pre-clinical data demonstrate profound hematopoietic tissue activation after myocardial infarction (MI), liberating leukocytes from bone marrow (BM) and spleen. These subsequently leads to accelerated atherogenesis. It is unknown whether such a relationship exists in humans. To investigate, we assessed arterial, BM, and splenic metabolic activity after acute coronary syndrome (ACS) with 18-FDG-PET/CT.
Methods: 67 individuals were imaged using FDG PET/CT: 22 patients within 10 days of ACS and 45 stable controls with, or with high risk of, coronary heart disease. Blinded to patient group, FDG uptake, as standardized uptake value (SUV), was measured in the spleen, BM, and the aortic wall, and control tissues - subcutaneous fat and pectoralis muscle. Between-group comparisons were made after blood background correction (SUVc).
Results: There were no significant differences in age (mean±SEM: 58±1 vs 62±2, p=0.08) or gender (% male: 73 vs 78, p=0.63) between ACS subjects and stable controls. However, after ACS, SUVc was increased in the spleen, BM, and arterial wall, while activity in control tissues did not differ (table 1). Moreover, both splenic and BM SUV significantly correlated with arterial inflammation and CRP while activity in control tissues did not (table 2).
Conclusion: These findings suggest, for the first time in humans, that cross-talk exists between sites of leukocyte production and inflammatory cell reservoirs, on one hand, and arterial inflammation on the other. This observation provides mechanistic insight into accelerated atherogenesis after MI and highlights a pathobiologic pathway that can be targeted for interruption.
- © 2013 by American Heart Association, Inc.