Abstract 17461: The Potential Role of Statin in Patients With Critical Limb Ischemia
Background: Revascularization is the optimal treatment to avoid major amputation for critical limb ischemia (CLI) patients. Although previous studies report that statin administration is associated with a reduced risk for cardiovascular events, the efficacy for CLI patients is unclear. In this study, we aimed to compare the outcomes in CLI patients with statin administration and without statin administration after endovascular therapy (EVT).
Methods: This study is a subanalysis from Endovascular Treatment for Infra-inguinal Vessel, in patients with critical limb ischemia, - A Prospective, Multi-center, 12 month follow-up Registry in Japan: Olive Registry. From November 2009 to December 2011, a total of 310 patients with CLI who underwent EVT for infrainguinal artery disease were enrolled. The outcome measures were limb salvage and major adverse limb event (MALE). Limb salvage rate was defined as freedom from above-ankle amputation and MALE was defined as major amputation or major reintervention including surgical procedure.
Results: The mean follow-up period was 294 ± 138 days. Sixty-five percent were male, 71% had diabetes, 52% underwent hemodialysis and 26% had statin administration. The mean age was 73.1 ± 9.8. Rutherford class IV was found in 38 patients, V in 217 patients and VI in 55 patients. Kaplan-Meier survival curve showed that the limb salvage rate at one year was 97.3% in the statin group, 89.7% in the without statin group (P=0.03). In adjusted model for the nonrandomized allocation of the administration of statin, limb salvage rate and freedom from MALE were statistically higher in the statin group (P<0.01, respectively).
Conclusion: Statin administration after infrainguinal angioplasty for CLI patients improved limb salvage rate and freedom from MALE.
- © 2013 by American Heart Association, Inc.