Abstract 17391: Extracellular Matrix Metalloproteinase 9 Levels Are Increased in Hypertensive Crisis
Introduction: High blood pressure is an important factor for the development of cardiovascular disease, due to vascular remodeling. However, the mechanisms of vascular remodeling have not been fully elucidated. Thus, the participation of metalloproteinases (MMPs), zinc-dependent endopeptidases in the degradation of extracellular matrix has been researched. An imbalance between the activation and inactivation of MMPs seems to occur, which may be related to vasomotor changes.
Objective: To identify the levels of MMP-9 in different blood pressure levels.
Method: We studied 58 controlled hypertensive (HT) individuals, 25 patients with resistant hypertension (RH), 60 with hypertensive emergency (EH) and 40 subjects with hypertensive urgency (HU), besides 40 normotensive (NT) individuals. The levels of MMP-9 were analyzed by calculating the averages. The comparison among the groups was performed by ANOVA and the Dunn’s post-test.
Results: Participants were between 22 and 90 years of age. The study included 58 HT individuals [mean age 59.5 years; 13 men (22.4%)], 25 HR [mean age 57.4 years; 10 men (40%)]; 60 with EH [mean age 62.3 years; 30 men (50%)] and 40 individuals with UH [mean age 56.2 years; 21 men (52.5%)], and 40 NT subjects [45.3 years; 7 men (17.5%)]. A difference in MMP-9 levels (p <0.0001) could be observed among the groups. There was also a difference between EH (244.9 ± 168.9 ng/mL) compared to NT group (114.6 ± 104.6 ng/mL; p <0.0001), EH vs HT (120.8 ± 68.67; p <0.0001) and EH vs HR (123.8 ± 87.3ng/mL; p = 0.0012). There was also a difference between HU (204.8 ± 126) and NT (p = 0.0005), HU vs HT (p = 0.01) and HU vs HR (p = 0.03).
Conclusion: The concentrations of MMP-9 show progressively higher in groups NT, HT, HR, UH and EH. Significant statistically differences were observed between individuals in the hypertensive crisis group (HU + HE) when compared with other groups. So, MMP-9 can be activated in the presence of higher blood pressure and inflammatory mechanisms.
- © 2013 by American Heart Association, Inc.