Abstract 17352: Diagnostic Value of Right Ventricular Strain Imaging in Patients With Suspected Arrhythmogenic Right Ventricular Cardiomyopathy
BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heritable cardiomyopathy characterized by the fibrofatty replacement of right ventricular (RV) myocardium leading to RV failure and arrhythmias. This study evaluated the potential utility of two-dimensional speckle-tracking echocardiography (2DSTE) to quantitatively assess their potential role in diagnosing ARVC.
METHODS: We retrospectively evaluated the echocardiographic data of 66 patients referred for ARVC. Of them, 37 patients (Group A) were diagnosed as ARVC based on the diagnostic criteria including significant MRI findings, while remaining 29 patients (Group B) were not diagnosed due to not meeting criteria. Routine echocardiographic RV parameters included Tei Index, RV end-diastolic and end-systolic area (RVEDA, RVESA) and RV fractional area change (RVFAC). 2D speckle-tracking strain was used to assess global longitudinal strain (GLS) and standard deviation of the time to peak strain in RV wall (T-SD).
RESULTS: In patients in Group A, GLS were significantly lower (-12.6±5.4 vs. -18.0±3.6, p<0.01) and T-SD were significantly greater (107.58±71.2vs. 45.0±23.3, p<0.01) compared with patients in Group B. However, there were no significant differences in Tei Index, RVEDA, RVESA, and RVFAC between 2 groups. A receiver operating characteristic curve analysis revealed that GLS>-17.0 was able to discriminate patients with ARVC with sensitivity of 81.1, specificity of 65.5 (AUC=0.78, p<0.0001)), and that T-SD>55.78 was also discriminate with sensitivity of 78.4, specificity of 72.4 (AUC=0.83, p<0.0001).
CONCLUSIONS: RV strain parameters may have potential clinical value in the assessment of patients with suspected ARVC.
- © 2013 by American Heart Association, Inc.