Abstract 17288: Green Tea Catechin Consumption Affects Metabolic Syndrome in Japanese Overweight and Obese Adults
Introduction: Metabolic syndrome (MetS), a cluster of cardiovascular risk factors, increases the risk of type-2 diabetes mellitus and cardiovascular disease (CVD) worldwide. Accumulating evidence indicates that catechins (flavan-3-ols) abundant in green tea improve fat metabolism; however, health benefits of catechins consumption on the chronic metabolic disorder have yet to be elucidated.
Hypothesis: Our aim was to assess the effect of long-term consumption of catechins on MetS among Japanese overweight and obese adults.
Methods: The study was a multicenter, randomized, double-blind, placebo-controlled, parallel study. After a 4-week run-in period, 166 Japanese overweight and obese men and women (mean BMI: 28.3 kg/m2, M 101/F 65) consumed a 350-mL bottle of green tea containing either 554 mg of catechins with 84 mg of caffeine (catechin group, n=83) or 87 mg of catechins with 84 mg of caffeine (control group, n=83) per day for 12 weeks. Data on all subjects were analyzed on an intention to treat basis.
Results: At the end of the study, body weight (-1.3 kg vs. -0.1 kg, p<0.001), waist circumference (-1.7 cm vs. -0.1 cm, p<0.001), systolic blood pressure (-6.0 mmHg vs. -3.4 mmHg, p<0.01), diastolic blood pressure (-3.6 mmHg vs. -1.4 mmHg, p<0.001), and visceral fat area measured by computed tomography scan (-8.3 cm2 vs. -0.3 cm2, p<0.01) were significantly lower in the catechin group than the control group. Total serum cholesterol concentration (-7.7 mg/dL vs. -0.3 mg/dL, p<0.05) was also significantly lower in the catechin group than the control group, but serum triacylglycerol and high-density lipoprotein cholesterol concentrations did not changed. Moreover, postprandial glucose response after a 75-g oral glucose tolerance test was significantly lower especially in subjects with impaired glucose tolerance in the catechin group than the control group. Finally, total prevalence of pre-MetS (central obesity and 1 criterion) and MetS (central obesity and 2-3 criteria) was on a moderately recovering trend in the catechin group than the control group (-20% vs. -11%, p<0.1).
Conclusions: Daily consumption of a catechin-rich beverage may be useful for managing MetS accompanied by insulin resistance-related obesity, linked to type-2 diabetes mellitus and CVD.
- © 2013 by American Heart Association, Inc.