Abstract 17219: Vitamin D Supplementation Improves Endothelial Function In Type 2 Diabetes - A Randomized Controlled Trial
Background: Cardiovascular disease is prevalent in type 2 diabetes, and both endothelial dysfunction and arterial stiffness may contribute in the pathogenesis. Studies indicate that low levels of vitamin D are associated with both type 2 diabetes and cardiovascular disease.
Aim: To evaluate the effect of vitamin D supplementation on endothelial function and arterial stiffness in subjects with type 2 diabetes in the DIVINE study.
Methods: Sixty-two subjects with type 2 diabetes and hypovitaminosis D (serum 25-hydroxy-vitamin D [25(OH)D] <50 nmol/L) were included in this randomized controlled trial (NCT 00992797). Thirty-three patients were randomized to treatment and received vitamin D (400 000 IU cholecalciferol) at baseline with dose escalation to elevate serum levels to more than 100 nmol/L after 4 weeks, whereas 29 patients received placebo. Endothelial function and arterial stiffness were measured at baseline and after six months. Endothelial function was assessed as the reactive hyperaemia index (RHI) using endothelial pulse amplitude testing (Endo-PAT). Arterial stiffness was estimated as carotid-femoral pulse wave velocity (cfPWV) and augmentation index (AIx) with applanation tonometry (SphygmoCor). Serum 25(OH)D was measured using the DiaSorin-RIA.
Results: Mean (SD) age in the treatment and placebo group were 57.5 (9.4) and 57.8 (10.0) years, 51.5 % (n=17) and 44.8 % (n=13) were females, diabetes duration was 11.4 (6.5) and 7.5 (5.7) years. Treatment with vitamin D significantly improved RHI and increased the serum 25(OH)D levels, but did not change cfPWV and AIx (Table 1). In multivariable linear regression analysis, the change in RHI was significantly associated with change in serum 25(OH)D (β [CI] = 0.009 [0.001-0.017], P=0.03).
Conclusion: Vitamin D supplementation improved endothelial function but not arterial stiffness in type 2 diabetes. Vitamin D might be a modifier of endothelial function in subjects with type 2 diabetes.
- © 2013 by American Heart Association, Inc.