Abstract 17096: Left Ventricular Dilatation and Increased Wall Thickness represent Early Echocardiographic Findings in Asymptomatic Alcoholics
Introduction: Alcoholic cardiomyopathy is a major cause of secondary non-ischemic cardiomyopathy. Early alcoholic cardiomyopathy is asymptomatic and reversible, and changes in heart structure and function at this stage can be characterized by 2-dimensional and Doppler echocardiography.
Methods: 40 asymptomatic alcoholics who had consumed alcohol equivalent to 60 grams of pure ethanol per day, at least 5 days a week for 5 years or more; and 40 age and sex matched controls underwent 2-dimensional and Doppler echocardiography. Alcoholics were divided based on amount of alcohol consumed (moderate drinkers: 60-100 grams/day and heavy drinkers: more than 100 grams/day), and the duration of alcohol consumed (short: 5-9 years, intermediate: 10-15 years and long: 16-28 years).
Results: Asymptomatic alcoholics had higher left ventricular internal dimension, end diastole (LVIDD) (p <0.0001), and left ventricular internal dimension, end systole (LVIDS) (p <0.05) compared to controls. Even short term (5-9 years) alcoholics had higher LVIDD (p <0.05) and LVIDS (p <0.05) than controls. Regression analysis revealed no relationship between increased LVIDD and duration or amount of alcohol consumed (r=0.304, SEE=4.51, p=0.903 and 0.534 respectively). Similarly, no relationship was found between increased LVIDS and duration or amount of alcohol consumed (r=0.158, SEE=49.45, p=0.894 for both duration and amount). Chronic alcoholics had thicker interventricular septum and posterior wall than controls (p <0.0001 and <0.001 respectively). Significant increases in posterior wall thickness compared to controls were seen first in the intermediate group (p < 0.05) indicating that this may be a later change compared to increased LVIDD and LVIDS. Diastolic dysfunction was diagnosed in 57.5% of alcoholics, the vast majority had impaired relaxation and pseudonormalization pattern (43.5% each). A linear relationship was elucidated between duration of alcoholism and severity of diastolic dysfunction (X2=9.916, p=0.0016).
Conclusions: In conclusion, increased LVIDD, LVIDS and interventricular septum were early findings in alcoholics asymptomatic for heart disease and the severity of diastolic dysfunction correlated with the duration of alcoholism.
- © 2013 by American Heart Association, Inc.