Abstract 16979: Enhanced Systemic Atherosclerosis in CD36 Deficient Patients With Acute Coronary Syndrome-Impact of CD36 Deficiency on Fat Intake
A class B scavenger receptor, CD36, which is a receptor for oxidized LDL and transporter of long-chain fatty acids, was newly identified as a receptor for lipid sensor on the taste buds. In animal experiments, CD36 deficiency (CD36-D) was associated with reduced risks for cardiovascular diseases (CVD); however, we often experience that the patients with CD36-D are accompanied with CVD. We hypothesized that CD36-D patients might have exaggerated energy surplus due to the alteration of sensitivity to lipid. We investigated the prevalence and severity of CVD and diet content in the patients with CD36-D with acute coronary syndrome (ACS).
Methods and Results: Of 3,015 patients with ACS underwent myocardial SPECT of 123I-BMIPP from May 2002 to May 2013 in the affiliated hospitals of Nagoya University, 31 patients (1.03%; mean age 63.7±12 yrs; 77.4% male) with type I CD36-D detected by the absent accumulation of 123I-BMIPP were enrolled. Age- and gender-matched ACS patients were compared as a control (n=40). Regarding risk factors for CVD including hypertension, dyslipidemia, diabetes, and obesity (BMI>28), the patients with CD36-D had more risk factors for CVD at entry (2.45±0.81 vs. 1.73±0.72, P=0.002). Based on the nutritional questionnaire, CD36-D group had the preference for “greasy food” contained more than 60% in fat of all calories (3.62±0.65 vs. 2.84±0.47 points, P=0.003). CD36-D patients had a higher prevalence of CVD than control group [cerebrovascular disease: 12/31 vs. 3/40 (P=0.002) and peripheral arterial disease: 7/31 vs. 2/40 (P=0.037)] with chronic kidney disease (8/31 vs. 3/40, P=0.032). During the follow-up period (mean 48±17 months), in CD36-D group, 26 cardiovascular events [cardiac event: 12 (38.7%), cerebrovascular events: 4 (12.9%), and peripheral arterial events: 2 (6.5%)] occurred, and 4 (12.9%) and 3 (9.7%) patients experienced cardiovascular and non-cardiovascular deaths, respectively.
Conclusions: CD36-D patients with ACS had a higher prevalence of CVD and preference for high fat diet than control, suggesting that CD36-D would affect the preference for the food and the progression of systemic atherosclerosis. Nutritional intervention would be required for the patients with CD36-D to prevent the progression of CVD.
- © 2013 by American Heart Association, Inc.