Abstract 16906: Gender Differences of Echocardiographic Characteristics in Non-Valvular Atrial fibrillation
Background: Female gender is a risk factor for thromboembolism in atrial fibrillation (AF). But the pathophysiological basis for increased risk in women is not well known. Increased left atrial (LA) size and diminished function may be important factors for predisposing patient in high risk of thromboembolism but sex difference in cardiac anatomy and function has not been investigated in AF patients. The aim of study was to evaluate the cardiac structural and hemodynamic differences between sexes in AF by eliminating well-known embolic risk factors of age, diabetes, hypertension and AF type
Methods: 144 (F/M;72/72) patients with non-valvular AF were selected among 502 patients in AF data sheet using propensity score matching. The two groups were matched by age, presence of diabetes or hypertension and type of AF. The size and function of left ventricle (LV) and LA were measured by trans-thoracic and trans-esophageal echocardiography.
Results: The mean age of study population was 61.7±8.4 years old. Number of paroxysmal and persistent AF were 37(51.4%) and 35(48.6%) patients in each group. There was no difference between sexes in LV mass index and ejection fraction (Table 1). But LA volume index (LAVI) was larger in female patients. Peak mitral E wave velocity, the ratio mitral E wave velocity and mitral annular tissue velocity (E/e’) were higher and deceleration time (DT) was shorter in female than that of male. It showed a trend that the presence of SEC was more frequent in female than male patients (p=0.059). (Table 1)
Conclusion: Female patients with AF had shorter DT and higher LAVI and E/e’ than that of males without differences in LV geometry and systolic function. These findings suggest that the worse diastolic function in female patient even in similar clinical setting appears to be one mechanism making favorable condition of LA stasis in female patient with AF.
- © 2013 by American Heart Association, Inc.