Abstract 169: Beta-Blocker Pre-Treatment Improves the Quality of Ventricular Fibrillation Waveform and Increase Defibrillation Success
Introduction: Studies have demonstrated that beta-blocker administered during CPR with epinephrine improves post-resuscitation myocardial function. However, it is unknown whether beta-blocker administered with epinephrine improves the ventricular fibrillation (VF) waveforms and therefore increases defibrillation success. In the present study, we investigated the effect of pre-treatment of beta-blocker on changes of VF waveforms prior to and during CPR.
Hypothesis: Beta-blocker improves the quality of the ventricular fibrillation waveform during CPR and therefore the success of defibrillation.
Methods: Eighteen male Sprague Dawley rats weighing between 450-550g were randomized into three groups: 1) Placebo group; 2) Epinephrine (20μg /kg) group; 3) Propranolol (1mg/kg) pretreatment + epinephrine (20μg /kg) group. Ventricular fibrillation (VF) was electrically induced. After 8 mins of VF, CPR was initiated for 8 mins, and up to three 2-J defibrillations were then attempted. Amplitude spectrum analysis (AMSA) at VF7, VF8, and PC1~PC8 were analyzed with the aid of Matlab software (Mathworks Inc., Natick, MA).
Results: All animals were resuscitated except one in the Placebo group. AMSA in propranolol+epinephrine group was significantly greater than that in the Epinephrine and the Placebo group at VF7, VF8 and PC1 (Table). There was no significant difference in the AMSA between the Epinephrine group and the Placebo group at PC1-PC8. Significantly fewer defibrillation attempts were observed in the Proranolol+epinephrine group than in the Epinephrine group and the Placebo group (Table).
Conclusion: Beta-blocker improved the quality of the ventricular fibrillation waveforms prior to and during chest compression along with the success of defibrillation.
- © 2013 by American Heart Association, Inc.