Abstract 16779: Testosterone Deficiency: A Critical Determinant of Aortic Stiffness in Men
Objective: Testosterone deficiency (TD) and increased aortic stiffness are predictive markers of cardiovascular disease. The influence of androgen level on the age and blood pressure related increase in aortic stiffness is unknown.
Methods: Total testosterone (TT) levels were measured in 455 men with no evidence of clinical atherosclerosis. Carotid-femoral Pulse Wave Velocity (PWVc-f) was measured as an index of aortic stiffness.
Results: In multivariate analysis PWVc-f was inversely correlated to TT after adjustment for confounders (β=-0.365, P < 0.001). In younger categories (< 50 yrs and 50-59 yrs), patients with TD had higher blood pressure-adjusted PWVc-f (P<0.001 and P=0.005, respectively) compared to subjects with normal TT whereas in older age categories, PWVc-f between TD patients and men with normal TT did not differ (left plot).
Furthermore, in men with a higher mean pressure (102-108 mmHg and > 108 mmHg), patients with TD had higher age-adjusted PWVc-f (P< 0.001) compared to subjects with normal TT whereas in men with lower mean pressure level, TD patients and men with normal had comparable PWVc-f values (right plot).
Conclusion: TT levels are independently associated with aortic stiffening. The effect of low testosterone concentration on aortic stiffness is emphasized in young men and subjects with higher blood pressure level. These findings underline the important role of testosterone as a marker of arterial damage.
- © 2013 by American Heart Association, Inc.