Abstract 16778: Atherosclerotic Plaque Distribution Pattern and Burden in the Carotid and Iliac-Femoral Territories Assessed by 2D/3D Ultrasound in Middle-Aged Population. The PESA (Progression and Early Detection of Subclinical Atherosclerosis) Study
Background: The significance of subclinical atherosclerosis in both carotid and iliac-femoral territories is not yet clear. A better characterization of the burden and distribution pattern in different vascular territories is necessary. The PESA study is a prospective cohort study in a middle-aged, symptomatic population, focusing on the early detection and progression of subclinical atherosclerosis throughout six years of follow up.
Methods: We report data from the first 2000 participants in the PESA study (40-54 yo, 35% women) at The “Centro Nacional de Investigaciones Nacionales” (CNIC), Spain. Screening for subclinical atherosclerosis was performed using 2D/3D vascular ultrasound switch in carotid and iliac-femoral arteries. Plaques were defined as any focal protrusion into the lumen with a thickness >0.5 mm. Plaque burden was classified according to tertiles of the sum of maximum plaque thickness.
Results: Distribution pattern of atherosclerosis in carotid and iliac-femoral arteries progresses by age and its widespread distribution occurs to all territories analyzed in clear association to age and gender (figure 1). Atherosclerosis is less prevalent in women tan in men and it is more frequent in iliac-femorals than in carotids for both genders. Stratifying by age, more men at 50-54 yo have disease than men aged 45-49 or 40-44 [85% vs 67% and 57% (p<0.001)]. Women, 50-54 yo have the same distribution patterns as men, 40-44 yo. Plaque burden was more predominant in iliac-femorals than in carotids [tertiles 2 and 3: 54% and 28% vs 17% and 7% (p<0.001)].
Conclusion: Atherosclerosis is extensive in the middle-aged population. It starts earlier in iliac-femorals in both genders. Atherosclerosis affects women 10 years later than men. This relatively young population, with subclinical disease, is a target for researching modifiable approaches with the aim of stopping atherosclerosis progression.
- © 2013 by American Heart Association, Inc.