Abstract 16731: Family History of Coronary Artery Disease - Does it Differ According to the Types of Coronary Artery Disease?
Background: It is accepted that the presence of a family history (FH) of coronary artery disease (CAD) is one of the risk factors for CAD. However, whether FH has an influence on the various types of CAD and how the FH affects the CAD status has not yet been fully elucidated. Therefore, we investigated the frequency of FH of CAD according to the type of CAD and studied the relationship between the presence of FH and CAD status and activity.
Methods: Three hundred and eight patients (mean age 68 years, 191 men), who underwent coronary angiography during evaluation of chest symptoms, were enrolled. Patients with cardiomyopathies and with known ECG abnormalities, were excluded. Each patient was questioned about the FH of CAD, and its presence was defined as having known CAD and sudden death affecting first-degree relatives. On coronary angiography, if organic coronary stenosis (>50% coronary stenosis) was absent, a spasm provocation test was performed to confirm the presence of vasospastic angina (VSA). According to the coronary angiography results, patients were divided into 3 subgroups: Group I, patients with organic coronary stenosis (n = 161); Group II, patients with VSA without organic coronary stenosis (n = 78); and Group III, patients without organic coronary stenosis or VSA (n = 69).
Results: The frequency of FH of CAD did not differ significantly between the 3 groups (Group I: 17.4%, Group II: 20.5%, Group III: 15.9%). Younger age was more frequently observed in patients with FH in Group I (63 ± 2 yrs vs. FH–: 70 ± 1 yrs, p < 0.001) but this was not noted in the other groups. In female patients, the presence of FH tended to be highest in Group II (Group I: 8%, Group II: 24%, Group III: 11%, p = 0.08). In Group I, the presence of FH was not associated with either the percentage of stenosis or the number of diseased vessels on the angiogram. In Group II, the presence of FH was associated with the duration of angina (FH+: 52 ± 15 months vs FH–: 16 ± 7 months, p = 0.0302).
Conclusions: These findings suggest that the frequency of FH of CAD does not differ according to the type of CAD but indicate that the impact of FH on disease activity may differ between the types of CAD.
- © 2013 by American Heart Association, Inc.