Abstract 16679: Age-Dependent Impact of Obesity on Aortic Stiffness
Background: South Asian’s develop cardiovascular disease (CVD) at young ages despite relatively low BMI. Aortic stiffness (AS) is a strong risk marker for premature CVD. We assessed the impact of obesity on AS and how such impact is influenced by age in a South Asian population.
Methods: We selected 5,841 South Indians (mean age 42 years; 58% women) not on therapy for CVD or its risk factors from a population-based cross-sectional survey for analysis. Following anthropometric measurements and body fat percent (BF%) assessment by bioelectrical impedance, all participants underwent haemodynamic screening including brachial and central blood pressure (BP), and aortic pulse wave velocity (aPWV) using a high-fidelity applanation tonometry.
Results: In a univariate analysis, body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR) and BF% correlated positively with aPWV (P<0.001). In a multivariate regression analysis, BMI (β=0.044; P<0.001), WC (β=0.024; P<0.001), WHR (β=1.97; P<0.001) and BF% (β=0.026; P<0.001), were independently correlated with aPWV. The influence of age on the relationship between obesity measures and aPWV was then explored in a series of multivariable regression models that included age X obesity factor interaction terms. In the models, adjusted for age, gender, mean BP, heart rate and fasting glucose, all obesity measures had significant interaction with age (P<0.001), except for BMI (P= 0.477). Subsequently, the relationship between each obesity factor and aPWV was explored separately for four age groups (Fig). As illustrated in the figure, obesity measures were strongly associated with aPWV in younger individuals, whereas the association was less marked in individuals above 50 and reversed in individuals over 70.
Conclusion: There is a positive, independent impact of obesity on AS and the impact is more significant in younger individuals, which could be one the potential causes for premature CVD in the South Asian Population.
- © 2013 by American Heart Association, Inc.