Abstract 16675: Acute Effects of Dietary Bisphenol A on Arterial Health
Background: Bisphenol A (BPA) is present in canned goods and detectable in the urine of >95% of US adults. Animal studies suggest a link between BPA and cardiovascular disease (CVD). Yet, in humans, to what extent BPA impacts CVD is relatively unknown. Arterial stiffness and pulse wave analysis are subclinical measures of arterial health and strong independent risk factors for CVD. We tested the hypothesis that canned soup consumption increases BPA concentrations and impairs arterial health.
Methods: Using a double-blinded crossover design, we compared the effects of 5 days of canned vs. fresh soup consumption in 14 healthy individuals (age > 18 yrs). Fresh soup was made to approximate the sodium, fat, and cholesterol content of canned soup. Urinary BPA was measured after each week. Arterial stiffness was measured by carotid to femoral pulse wave velocity (PWV) using applanation tonometry; carotid diameter was measured by B-mode ultrasound; radial artery waveforms were used for pulse wave analysis (augmentation index) and to calculate central and brachial pressures. Data were compared using paired t tests.
Results: BPA was undetectable in fresh soup (<0.01 ug/ml), but was 0.98 ± 0.72 ug/ml in canned soup. Thus, a 12-oz portion of canned soup contains approximately 350 ug of BPA (4.4 uM). After a week of fresh soup, urinary BPA was 1.51 ± 0.18 ug/L. In contrast, after a week of canned soup, urinary BPA increased to 9.66 ± 2.62 ug/L (p = 0.003). PWV did not differ between canned and fresh soup (6.0 ± 0.2 vs. 6.1 ± 0.2 m/s, p = NS). Further, central systolic pressure (96 ± 3 vs. 97 ± 2 mmHg, p = NS) and brachial systolic pressure (109 ± 3 vs. 110 ± 2 mmHg, p = NS) were not changed by diet. However, after a week of canned soup, aortic augmentation index (corrected for heart rate, a measure of pulse wave reflection) was increased (-1.4 ± 4 vs. 2.1 ± 4%, p = 0.020). Further, after a week of canned soup, carotid diameter was reduced (5.82 ± 0.01 vs. 5.67 ± 0.01 mm, p = 0.018) and, consequently, carotid circumferential strain was increased (7.79 ± 0.70 vs. 9.50 ± 0.86%, p = 0.035).
Conclusion: These findings indicate that acute BPA consumption negatively influences the mechanical forces of conduit arteries. This suggests that prolonged exposure to dietary BPA may be a contributing factor in the progression of CVD.
- © 2013 by American Heart Association, Inc.