Abstract 16449: Dermatomyositis and Risk of Ischemic Stroke: A Nationwide Study in Taiwan
Objective: Few data are available on the risk of ischemic stroke following diagnosis of dermatomyositis (DM). Therefore, we investigated whether DM increased the risk of ischemic stroke in a large, nationwide cohort study.
Methods: From the Registry of Catastrophic Illness in Taiwan, we obtained data for 1,002 patients with newly-diagnosed DM from 2000 to 2006 who did not have ischemic stroke prior to diagnosis of DM. We also obtained data for one age-, gender-, comorbidities-, and enrollment date-matched control without systemic autoimmune diseases and previous AMI per 10 DM patient from the Longitudinal Health Insurance 2000. All study subjects were followed up from the date of enrollment for up to 5 years or until they developed death or to the end of 2006, whichever was earlier. We used Cox’s regression model with adjustment for age, gender and comorbid disorders to investigate if DM was an independent factor in determining the risk of developing AMI.
Results: A total of 1,002 subjects with DM and 10,020 controls were identified. Among these patients, 206 (28 DM patients and 181 controls) developed ischemic stroke during the maximal 5 year (median 3.1 years, interquartile range, 1.7 - 4.9 years) follow-up period. Patients with DM had a higher incidence of ischemic stroke occurrence compared to that of controls (5.8/1000 versus 10.8/1000 person-years, P=0.002). Multivariate analysis adjusted for baseline covariates indicated that DM increase risk of ischemic stroke (adjusted hazard ratio: 2.14, 95% confidence interval: 1.44-3.19, P <0.001).
Conclusion: We conclude that DM is associated with a higher risk of subsequent ischemic stroke.
- © 2013 by American Heart Association, Inc.