Abstract 16428: Impact of Very Early Endotherialization After Nobori Stent Implantation on its Low Frequency of In-Stent Thrombosis: Evidence From Super Acute Examination in a Porcine Model
Background: Drug-eluting stents significantly reduce restenosis but may increase late thrombosis and delayed restenosis. Nobori coronary stent coated with a bioresorbable polymer, polylactic acid, and the antiproliferative agent Biolimus A9 has the potential to reduce thrombosis by degradation of polymer over the period of 6 to 9 months. The clinical efficacy and safety of the Nobori stent were evidenced by the absence of both clinically driven target lesion revascularization and stent thrombosis up to 9 months follow-up. However, there have been no data regarding with the vessel response and endthelialization at early phase after Nobori implantation.
Methods and Results: Eight Nobori stents (2.75 mm x 8mm for 6, and 3.9 mm x 8 mm for 2) were implanted in pigs (mean weight 24 kg) that were followed for either 2 days or 14 days. Oral aspirin (200 mg) and clopidogrel (300 mg) were administered starting 3 days before the procedure, and oral aspirin (200 mg) and clopidogrel (75 mg) were continued daily until the end of the study. Stented coronary artery segments were processed for plastic embedding, staining, and histomorphometric analysis. Endotherialization was evaluated by stereoscopic microscope and scanning electron microscope. In addition, neointimal thickness was evaluated by using sections stained by hematoxyline and eosin. Endothelialization was incomplete in all stents at 2 days, however, fully complete for all stents at 14 days. The characteristics of endothelium were closely similar to healthy endothelium. Mean neointimal thickness was 54.9 μm at 14 days.
Conclusion: Nobori demonstrates very early endotherialization in a porcine model, implicating that Nobori stent implantation can be related to low frequency of in-stent thrombosis. The use of Nobori stents may have a potential benefit even at early phase before the degradation of polymer as well as long-term benefit.
- © 2013 by American Heart Association, Inc.