Abstract 16368: Pericardial Fat Volume is an Independent Predictor for Clinical Recurrence of Atrial Fibrillation and Obstructive Sleep Apnea in Patients Who Underwent Catheter Ablation: Over 600 Case Study
Background&objectives: Although pericardial fat volume (PFV) has been suggested to be associated with prognosis after radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF), the pathophysiologic mechanism remains to be elucidated. The purpose of this study was to characterize the association of PFV and other clinical variables including left atrial (LA) remodeling in patients with AF.
Methods: We included 686 patients (76.9% male, 57.2±11.1 years old, 68.1% paroxysmal AF) who underwent AF ablation, and compared PFV (CT) with LA volume (CT), LA voltage (NavX), apnea-hypopnea index (AHI), or other clinical variables. The patients were followed up with rhythm monitoring stick to 2012 ACC/AHA/ESC guidelines.
Results: 1.During 19.1±8.8 months follow-up, clinical recurrence rate was 25.7% (use of anti-arrhythmic drug in 65.3%). Persistent AF(OR 2.11, 95%CI 1.39-3.19, p<0.001) and PFV (OR 1.007, 95%CI 1.003-1.012,p=0.002) were independent predictors for AF recurrence after RFCA. 2. In multiple linear regression analysis, PFV was independently correlated with age(B=0.64, 95%CI 0.340-0.943, p<0.001), male gender (B=22.28, 95%CI 15.129-29.431, p<0.001), LA volume (B=0.894, 95%CI 0.368-1.420, p=0.001) and body mass index (B=0.894, 95%CI 4.526-6.631, p<0.001). 3. PFV was significantly greater in male patients with recurrence than in those remain in sinus rhythm (p=0.003), but there was no difference in female gender. 4. AHI was linearly correlated with age (B=0.24, 95%CI 0.10-0.47, p=0.041) and PFV (B=0.07, 95%CI 0.01-0.13, p=0.021).
Conclusion: PFV was independent predictor for AF recurrence after catheter ablation, associated with age, LA remodeling and body mass index, especially in male patients.
- © 2013 by American Heart Association, Inc.