Abstract 16357: Association Between Obstructive Sleep Apnea and the Atrial Fibrillation Recurrence After Catheter Ablation
Introduction: Obstructive sleep apnea (OSA) is known as a risk factor of atrial fibrillation (AF). However, the sole impact of OSA on AF is not fully elucidated because OSA usually accompanies other risk factors of AF. In this study, we investigated the association between OSA and the AF recurrence after catheter ablation.
Method: A total of 194 patients (mean age 58.1±10.3 years, male 75.8%), who underwent catheter ablation of AF were enrolled. The patients underwent echocardiography and overnight ambulatory polysomnography before ablation procedure. These patients were followed every 3 months at the outpatient clinic. The AF recurrence was defined as any episodes of AF on ECG at the 6 months after catheter ablation.
Results: We divide the study subjects into 3 groups defined as mild (AHI<10/h), moderate (10<AHI<30), or severe (AHI>30) OSA based on apnea-hypopnea index (AHI). The results showed that 64 (33%) and 31 (12.9%) of these patients had moderate and severe OSA, respectively. Patients with severe OSA had higher prevalence of hypertension (41% vs 57.8% vs 64%, respectively; p=0.031). However, the recurrence rate after ablation was not different between the three groups. Mean duration of follow-up was 16.4±4.9 months (ranges 8-32). The Kaplan-Meier analysis of time to first recurrence during the follow-up period also showed no significant difference in AF recurrence according to the degree of severity of OSA. In multivariate logistic regression analysis, the type of AF (Odd ratio [OD] = 3.32, confidence interval [CI]: 1.05-10.53; p=0.042) and early recurrence of AF (OD = 4.53, CI: 1.71-12; p=0.002) were closely associated with the AF recurrence. Severity of OSA was not a predictor of the AF recurrence.
Conclusion: This study showed that severity of OSA was not associated with the recurrence of AF. Therefore, the relationship between OSA and AF should be further investigated. Treatment of OSA for the sole indication of lowering AF recurrence may need to be reconsidered.
- © 2013 by American Heart Association, Inc.