Abstract 16344: Maternal History of Myocardial Infarction and Incident Atrial Fibrillation According to Blood Pressure Category in a General Urban Population: The Suita Study
Background: Myocardial infarction (MI) is an increased risk of atrial fibrillation (AF). However, no prospective study has examined the relation between a parental history of MI and the incidence of AF in a general population. We assessed the hypothesis that a parental history of MI is associated with an increased risk of incident AF according to blood pressure (BP) category in a general population.
Methods: A total of 6,918 participants (30 to 84 years old) initially free of AF were prospectively followed up for incident AF in the Suita Study. Standard 12-lead electrocardiograms were obtained from all subjects in the supine position. Each record was coded independently by 2 well-trained physicians using the Minnesota Code. Participants were diagnosed with AF if AF or atrial flutter was present on electrocardiograms obtained during a biannual routine health examination or if AF was indicated as a present illness by either annual questionnaire responses or participants’ medical records. Well-trained nurses obtained information on parental history of MI and on the participants’ lifestyle. BPs were taken as the average of the second and third measurements, which were defined by the following criteria: normal BP (<120/80 mm Hg), prehypertension (120-139/80-89 mm Hg), and hypertension (≥140/90 mm Hg and/or antihypertensive drug user). Cox proportional hazard ratios (HRs) and 95% confidence intervals (CIs) were analyzed after adjusting for age, sex, body mass index, BP categories, diabetes, hyperlipidemia, smoking, and drinking at baseline.
Results: In 87,341 person-years of follow-up, 245 incident AF events occurred. A maternal history of MI was of marginal significance to the incidence of AF in both sexes (adjusted HRs, 1.72; 95% CIs, 0.97-3.02). Compared with normotensive subjects without a maternal history of MI, the adjusted HRs (95% CIs) of incident AF in hypertensive subjects were 1.38 (1.05-1.82) for those without a maternal history of MI and 3.04 (1.53-6.04) for those with a maternal history of MI. None of the significant association was observed in paternal history of MI.
Conclusions: A maternal history of MI is a predictor of incident AF among hypertensive subjects. For persons with a maternal history of MI, BP control would be important for AF prevention.
- © 2013 by American Heart Association, Inc.