Abstract 16265: Assessment of Pressure Volume Relation Under Various Pharmacological Conditions Using Mini-Pressure Wire and 3D-Echocardiography - Comparative Study With Conductance Technology in Piglets
Introduction: Pressure-volume relations (PVR) provide vital information regarding cardiac pathophysiology and function. In children, acquiring PVR by conductance technology is - due to catheter size - restricted to an older age. Aim of this pre-clinical study was the assesment of the accuracy of PVR - calculated from 3D volume data with simultaneously obtained pressure data by mini pressure wire.
Methods: In 14 piglets (body weight: 6.1±1.1kg) parameters including dp/dt max, systolic myocardial elastance (Ees), effective arterial elastance (Ea), relaxation constant Tau and ejection fraction (EF) were determined in different hemodynamic conditions: at rest (baseline), under adrenergic stimulation (epinephrine) and beta-adrenoceptor blockade (esmolol). Measurements were repeated with conductance technology immediately after echo measurements.
Results: Computation of pressure-volume curves by 3D echocardiography and mini-pressure wire was feasible, reproducible and comparable to results obtained by conductance technology in the juvenile swine. (Figure) Pressure volume loops provided detailed information about systolic, diastolic function and ventricular volumes under resting conditions as well pharmacological adrenocpetor stimulation and blockade. (Table )
Conclusions: In conclusion, calculation of PVR by 3D echocardiography and mini pressure wire is feasible and reproducible. Due to its less invasive character in comparison to conductance catheter technology, this methodology has the potential to be implemented into daily practice, to provide essential information on cardiac function and thus potentially contribute to clinical decision-making.
- © 2013 by American Heart Association, Inc.