Abstract 16236: Early Age-Related Macular Degeneration and Incident Stroke: A Systematic Review and Meta-Analysis
Background: Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness in people over 65 years of age in the United States and has been associated with cardiovascular risk and decreased survival. There is conflicting data, however, regarding the contribution of early macular degeneration to the prediction of stroke.
Aim: To determine whether early AMD is a risk indicator for incident stroke in a meta-analysis of available prospective cohort studies published in the English literature.
Methods: We performed a systematic literature search of all studies published in English with Pub Med from 1966 to December 2012, reporting stroke incidence in patients with macular degeneration. Two investigators independently extracted the data. A random effects model was used to report Odds ratios, with corresponding 95% confidence intervals. Meta-regression using a mixed linear model was used to understand potential heterogeneity amongst studies.
Results: We identified 10 studies that reported stroke incidence in patient with and without early AMD (N=131,050). No significant association was found between early AMD with incident stroke. Combined, these 10 studies demonstrated random effects OR 1.12 (CI 0.86- 1.47) p = 0.40. Significant heterogeneity was noted with the outcome (I2=87%). Metaregression on baseline covariates of age, sex, and year of publication did not significantly relate to heterogeneity.
Conclusions: We found no significant relationship between early AMD and incident stroke. Further studies are needed to clarify other causes of decreased survival in patients with AMD.
- © 2013 by American Heart Association, Inc.