Abstract 16230: Hypothyroidism Associated With Lower Mortality in Patients With Acute Myocardial Infarction
Background: Several reports have linked hypothyroidism and cardiovascular disease including data suggesting increased mortality from coronary artery disease in patients with hypothyroidism. However, it is not clear if hypothyroidism has any short-term prognostic implications in patients presenting with acute coronary syndrome. We sought to examine the impact of hypothyroidism on mortality in patients presenting with AMI.
Methods: The Nationwide Inpatient Sample, part of the Healthcare Cost and Utilization Project, is the largest publicly available inpatient database designed to provide information on characteristics and outcomes of patients discharged from United States community hospitals (non-Federal, short -term, general and specialty). Using the Nationwide Inpatient Sample, we identified 374061 adult patients presenting with AMI, both ST elevation and non-ST elevation myocardial infarction (NSTEMI) in the calendar years 2008 to 2010 and they constitute our study population. Among those, 21011 patients had a diagnosis of hypothyroidism.
Results: The in-hospital mortality rate for patients with hypothyroidism in univariate analysis was slightly higher than those with no hypothyroidism (5.9% vs. 5.6%, respectively. P<0.004). However, after adjusting for pertinent clinical and procedural variables using logistic regression analysis, hypothyroidism emerged as an independent predictor of lower mortality (p<0.001, OR 0.84 [0.798 - 0.883)
Conclusion: In this cohort representative of the US population, hypothyroidism was an independent predictor of lower in-hospital mortality in AMI patients.
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- © 2013 by American Heart Association, Inc.