Abstract 16199: Cardiorespiratory Fitness and Highly Sensitive Cardiac Troponin Levels in a Preventive Medicine Cohort
Introduction: Both cardiorespiratory fitness (CRF) and high sensitivity cTnT (hs-cTnT) associate with risk of all-cause and cardiovascular (CV) mortality as well as incident heart failure. Proposed mechanisms for the CV benefits of CRF include favorable effects on cardiac structure as well as remodeling and prevention of subclinical cardiac injury. We hypothesized that CRF would inversely associate with hs-cTnT (a marker of CV injury) in healthy adults ≥ 50 years old.
Methods: We evaluated 2498 participants (25% female, mean age 59 years old, and free of known CV disease) from the Cooper Center Longitudinal Study between August 2008 and January 2012, with a Balke treadmill test. hs-cTnT was measured from plasma obtained prior to the treadmill. CRF was estimated from treadmill time and categorized in high fit (quintile (Q) 4-5), moderate fit (Q 2-3), and low fit (Q 1). Logistic regression was used to estimate the association of CRF with high hs-cTnT (≥ 14 ng/L), the recommended clinical cut-point.
Results: The overall prevalence of detectable hs-cTnT (> 5 ng/L) was 50.6% (60.2% in men; 21.1% in women) and of high hs-cTnT was 3.7%. Higher CRF was inversely associated with hs-cTnT, based on mean hs- cTnT (figure 1a) and hs-cTnT>14 ng/L (figure 1b). After adjustment for age, gender, smoking, BMI, BP, glucose, and cholesterol, higher CRF remained inversely associated with high hs-cTnT (Adjusted OR for high vs low CRF 0.41, 95% CI 0.18-0.91)
Conclusions: In cross sectional analyses of healthy older adults, CRF inversely associated with hs- cTnT. Larger and prospective studies are needed to fully evaluate whether improving CRF is an effective strategy to prevent or limit chronic subclinical cardiac injury.
- © 2013 by American Heart Association, Inc.