Abstract 16195: Relationship Between Left Ventricular Mass and Central Blood Pressure During Exercise
Background: We reported that central blood pressure after exercise increases with age. On the other hand, it is said that the elevation of central blood pressure had association with the increase of left ventricular mass index (LVMI). There is less clear whether left ventricular mass has effect on central blood pressure and pulse pressure amplification (PPA) after exercise.
Methods: 139 patients (Men 85, Women 54) underwent exercise stress test and echocardiography within 1 week. The exclusion criteria indicated ejection fraction<50%, moderate or severe aortic and mitral valvular lesions, hypertrophic cardiomyopathy and old myocardial infarction. We divided them into two group, control and left ventricular hypertrophy (LVH) group by LVMI. They underwent symptom-limited treadmill exercise test with Bruce protocol and measured both brachial systolic blood pressure (bSBP) and central systolic blood pressure (cSBP) by HEM-9000AI at rest and after exercise. PPA was defined as the ratio of brachial to central pulse pressure. LVH was defined as>115g/m2 for men and >95g/m2 for women, using the LVH criteria of American Society of Echocardiography.
Results: bSBP, cSBP and HR at rest were not significant difference(p=0.20, 0.11, 0.13). bSBP and HR after exercise were not significant difference (p=0.18, 0.10), however, cSBP in the LVH group after exercise were significant higher than those in the control group (Control vs LVH, 145±18 vs 161±22mmHg, p<0.001). Moreover, LVMI were significant inversely correlated with PPA for both men and women(r=-0.45, p<0.01; r=-0.33, p<0.01)(Figure). By multivariate analysis, for men, LVMI was predicted factor of PPA after exercise, independence of age, height, BMI, ARB/ACE-I, Hypertension, EF and bSBP at rest (β=-0.37, p<0.01).
Conclusion: PPA after exercise was inversely related to LVMI. Patients with LVH may have excessive cardiac load during exercise even if the same systolic pressure in the arm.
- © 2013 by American Heart Association, Inc.