Abstract 15991: Post Transplant Survival Using the Berlin Heart Pediatric Ventricular Assist Device as a Bridge to Cardiac Transplantation
Objective: The Berlin Heart (BH) Pediatric Ventricular assist device is a pneumatically driven blood pump approved by the U.S. Food and Drug administration as a bridge to cardiac transplantation in the pediatric population. As the clinical outcomes of this device continue to be evaluated in the United States, data on post transplant survival are needed.
Methods: The Organ Procurement and Transplantation Network (OPTN)/United Network for Organ Sharing (UNOS) database was used to identify patients less than 18 years of age undergoing orthotopic heart transplantation (OHT) from June 2004 to June 2012. Patients successfully bridged to cardiac transplantation with the BH were identified. A randomly selected matched cohort of patients undergoing OHT without pre-transplant mechanical circulatory support (non-MCS) was also identified. The difference in post-transplant survival between the two groups was compared.
Results: There were 2,885 pediatric heart transplants during the study period. Of these, 167 patients were bridged to cardiac transplantation with the BH. One hundred seventy six patients were included in the non-MCS cohort. The mean age of the BH cohort was 3.67 years vs. 4.02 years for the non-MCS cohort. The number of patients supported with inotropes (70 vs. 82, p = 0.38) was the same between the BH cohort and the non-MCS cohort respectively. At the time of transplantation, end organ function was equivalent with similar creatinine levels (0.55 vs. 0.74, p = 0.32) and total bilirubin (1.07 vs. 1.20, p = 0.48). The 30 day, 1-year, and 5-year post-transplant survival was 97%, 90% and 69% in the BH cohort vs. 97%, 90%, and 76% in the non-MCS cohort (p value = 0.604).
Conclusions: Short- and mid-term post transplant survival using the Berlin Heart Pediatric Ventricular Assist Device as a bridge to cardiac transplantation in children is equivalent to patients who undergo orthotopic heart transplantation without pre-transplant mechanical circulatory support.
- © 2013 by American Heart Association, Inc.