Abstract 15987: Family History of Peripheral Arterial Disease: Number of Affected Relatives and Younger Age are Associated With Greater Odds of Peripheral Arterial Disease
Background: We previously reported that family history of peripheral arterial disease (PAD) is associated with presence of PAD, independent of conventional risk factors. In the present study, we investigated whether number of affected relatives and age of individuals modified the association of family history of PAD with presence of PAD.
Methods: The study cohort included 2296 patients (69±10 y, 63% men) with PAD and 4390 controls (66±11 y, 62% men) identified from non-invasive vascular and stress ECG laboratories, respectively. PAD was defined as a resting/post-exercise ankle-brachial index (ABI) ≤0.9, a history of lower extremity revascularization, or having poorly compressible leg arteries. Controls were patients with normal ABI or no history of PAD. Family history of PAD was obtained using a detailed questionnaire and defined as having at least one first-degree relative who had undergone revascularization or stent placement for PAD before age 65. Logistic regression analyses were used to evaluate whether the association of family history with presence of PAD was modified by number of affected relatives and/or age, independent of conventional risk factors.
Results: Family history of PAD was present more often in PAD patients than in controls (10.3% vs. 4.9%, respectively) with a resulting odds ratio (OR) (95% confidence interval) of 2.20 (1.81-2.66). The association remained significant after adjustment for age, sex, body mass index, smoking, diabetes, hypertension and dyslipidemia; OR: 1.96 (1.60-2.42). The association was stronger in younger individuals (age <68 y); adjusted OR: 2.45 (1.79-3.38) and 1.61 (1.22-2.12), for young and old group, respectively. A greater number of affected relatives with PAD was also associated with higher odds of presence of PAD; adjusted OR: 1.86 (1.48-2.33) and 2.56 (1.60-4.11) for patients with 1 and ≥2 affected relatives with PAD, respectively.
Conclusion: The association of family history of PAD with presence of PAD was stronger in younger individuals and in those with ≥2 affected relatives. These findings suggest that shared genetic and environmental factors influence susceptibility to PAD.
- © 2013 by American Heart Association, Inc.