Abstract 15982: Association of Electrocardiographic Parameters With Cardiac Troponin-T Measured With a High Sensitivity Assay in the Atherosclerosis Risk in Communities Study
Objectives: Troponin-T (c-TnT) is associated with cardiovascular (CV) events [including heart failure (HF)] and death in the general population. We evaluated the association between resting ECG parameters and c-TnT measured using a high sensitivity assay in the Atherosclerosis Risk in Communities (ARIC) Study, a population based study of cardiovascular disease (CVD) incidence.
Methods: In a population of 10, 281 subjects, c-TnT assays and standard, resting, supine 12-lead ECG were performed at visit 4 (1996-1998). Association between ECG markers of ischemia [(T wave, ST-T wave changes and Q waves), HF [(QRS duration, left ventricular hypertrophy (LVH), bundle branch block (BBB)] and sudden cardiac death [(SCD) (corrected QT interval)] and c-TnT were analyzed using logistic regression models, adjusted for CVD risk factors.
Results: The mean age of the population was 62.7(±5.6) years; 42% had hypertension, 16% diabetes, 14.7% current smokers with 8.7% having prevalent CVD. Detectable c-TnT level (≥3 ng/L) was found in 6937 individuals (67%) and several ECG parameters were significantly associated with c-TnT. Significant associations were noted between QRS duration, presence of BBB, corrected QT interval, ST segment changes, T-wave changes and presence of Q waves and c-TnT. (Table )
Conclusions: Several ECG markers of SCD, ischemia and HF are associated with c-TnT, independent of traditional CVD risk factors in the ARIC study. These findings further establish that mechanisms beyond ischemia mediate the association between c-TnT and incident CV events.
- © 2013 by American Heart Association, Inc.