Abstract 15899: Effect of Popular Diets on Large HDL Particle Levels
Objective: Increases in large HDL particles are favorably associated with reduced CVD event risk and coronary plaque burden. The objective of this study was to determine the effectiveness of the Atkins, Zone, Weight Watches, and Ornish diets for increasing blood levels of large HDL particles at 1 year.
Methods: Two-dimensional gel electrophoresis was used to measure concentrations of the alpha-1 subfraction of ApoA1-containing HDL particles at baseline and 1 year in serum samples collected during the previously published Tufts Popular Diet Trial, in which 93 participants completed a randomized 12-month dietary advice intervention ranging widely in carbohydrate, fat and protein intake. Dietary intake was assessed via 3-day diet records.
Results: Although 1-year weight loss did not differ between diet groups (mean 5%), increases in large HDL particles (Atkins 36%, Zone 32%, Weight Watchers 16%, Ornish 2%) paralleled the degree of carbohydrate restriction across the four diets (p=0.03 for trend). Regression analysis indicated that magnitude of carbohydrate restriction (percentage of calories as carbohydrate at 12 months) and weight loss were each independent predictors of 1-year increases in large HDL concentration. Changes in HDL cholesterol concentration were not highly correlated with changes in large HDL particle concentration (r=0.47, p<.01).
Conclusions: Carbohydrate restriction and weight loss were independent predictors of 1-year increases in large HDL particles. Such improvements in HDL metabolism were often not detectable via changes in HDL cholesterol levels.
- © 2013 by American Heart Association, Inc.