Abstract 15880: Increased Vascular Stiffness in Non-Hypertensive Offspring of Hypertensive Parents: The Framingham Heart Study
Background: Parental history of hypertension (HTN) and increased arterial stiffness (AS) are risk factors for new-onset HTN. It is unclear if a parental history of HTN is associated with AS (measured via applanation tonometry) in non-hypertensive individuals. We hypothesized that non-hypertensive offspring of hypertensive parents will have increased AS compared to individuals with non-hypertensive parents.
Methods: We evaluated 1564 non-hypertensive Framingham Third Generation (Gen 3) cohort participants (mean age 38 years; 55% women) with both parents enrolled in the Framingham Offspring (Gen 2) Study. We defined parental HTN as a SBP of ≥140 mmHg, DBP ≥90 mmHg and/or use of anti-hypertensive medications during serial Gen 2 examinations. Gen 3 participants underwent assessment of AS at the their first examination. We related AS measures (dependent variables; mean arterial pressure [MAP], forward wave amplitude [FWA], augmentation index [AI], and carotid-femoral pulse wave velocity [CF-PWV]) to parental HTN status using multivariable logistic regression analysis estimating the odds ratio (OR) for being in the sex-specific upper quartile of each AS measure given a parental history of HTN.
RESULTS: In age, height and weight-adjusted models, a parental history of HTN was associated with higher odds of being in the upper quartile of MAP, FWA, AI and CF-PWV, respectively (Table ). In multivariable (MV)-adjusted models, the association of parental HTN with greater odds of higher MAP, FWA and AI remained robust, whereas the association with CFPWV was attenuated (Table ).
Conclusions: Non-hypertensive offspring with a parental history of HTN have increased AS, a precursor of future HTN. Additional studies are warranted to evaluate if increased AS may serve as a marker of future HTN risk for the risk stratification of individuals with a positive family history of HTN.
- © 2013 by American Heart Association, Inc.