Abstract 15816: Repetitive Ct-Examinations Over a 5 Year Period Show Low Individual Change in Percentile of Coronary Artery Calcification Score in Subjects With Prevalent Coronary Calcification - The Population Based Heinz Nixdorf Recall Study
Background: Progression of coronary artery calcification (CAC) is associated with increased risk for cardiac events. While the CAC-score increases with age, intra-individual changes in CAC percentile over time to the best of our knowledge have not been investigated.
Objective: To describe the distribution of change in age and gender specific intra-individual CAC percentile in a European general population cohort over a 5 year follow up period.
Methods: We included subjects from the population based Heinz Nixdorf Recall study with CAC >0 at baseline examination. CAC was quantified from non-contrast cardiac EBCT using the Agatston method. Age and gender specific percentiles of CAC were determined for both CT scans independently. Consecutively, the intra-individual difference of percentiles was calculated. Distribution of intra-individual change in CAC percentile was described for the overall cohort as well as stratified by quartiles of CAC percentile at baseline.
Results: We included 2245 subjects (60 ± 7 years, 58% male) with prevalent CAC at baseline examination. Change in CAC percentile was uni-modal and symmetrically distributed with a mean of -0.94 ± 15.5 (median (q1; q3): -1 (-8; 6)), while 10th vs. 90th percentile referred to a change in CAC percentile by -18 and 16, respectively. When stratifying changes in CAC percentile by quartiles of CAC percentile at baseline, subjects with low CAC percentile showed a right-skewed distribution of change in CAC percentile, while a smaller variation of CAC percentile was observed in subjects in the highest quartile compared to the other groups (Figure 1). Changes in CAC percentile >40 percent were rare in the overall cohort (<-40: 38 subjects (1.7%), >40: 28 subjects (1.3%), Figure 1).
Conclusion: In subjects with prevalent CAC, little variation in intra-individual CAC percentiles over a 5 year period is observed. These findings may influence the discussion about repetitive CAC scoring and adequate time windows.
- © 2013 by American Heart Association, Inc.