Abstract 15802: Sleep Apnea and Risk of Aortic Dissection: A Nonrandomized, Pair-Matched Cohort Study
Background: Sleep apnea(SA) has been reported to be associated with increased prevalence of aortic dissection(AD) in studies that were criticized for either their small sample size or lack of prospective observation. Using a nationwide, population-based database and a long-term prospective cohort design, our study strived to explore the relationship between SA and the subsequent development of AD.
Methods and Results: From 2000 to 2007, we drew a study cohort consisting of 15,848 newly diagnosed SA cases from Taiwan’s National Health Insurance Research Database. For the control group, another 39,826 subjects without SA were matched for age, sex, and comorbidities. The two cohorts were followed-up to observe the occurrence of AD. During an average 3.59 2.41 years of follow-up, we observed a total of 33 cases of new AD occurrence [ SA(22, 0.1%) vs. non-SA(11, 0.1%), P=0.669) ] and the incidence of AD was similar for both groups. After adjusting for age, sex, and comorbidities, only age(hazard ratio [HR] 1.03; 95% CI, 1.01-1.06; P=0.006), male gender(HR 2.49; 95% CI, 1.07-5.79; P=0.034), and hypertension(HR 6.28; 95% CI, 2.36-16.67; P<0.001) were independently associated with AD diagnosis. SA was not associated with higher risk of developing future AD.
Conclusion: SA was not associated with increased risk of AD using a large-scale nationwide cohort database. Larger prospective studies or meta-analyses are recommended to confirm our findings.
- © 2013 by American Heart Association, Inc.