Abstract 15796: The Inflammatory Characteristics of Distinct Abdominal Adipose Tissue Depots Are Distinctively Related to Risk Factors for Cardiovascular Disease
Introduction: Obese patients are at increased risk for cardiovascular events, although the adipose tissue (AT) depot-specific contributions are partly understood. In this study, we investigated the relation between morphological and functional characteristics of four abdominal AT depots and clinical characteristics in patients undergoing abdominal aortic surgery.
Hypothesis: Distinct adipose tissue depots are morphologically and functionally different and consequently relate distinctively to risk factors for CVD.
Methods: In 30 patients undergoing undergoing abdominal aortic surgery, biopsies were retrieved from subcutaneous AT (SCAT), and 3 visceral depots: omental (OAT), mesenterial (MAT) and perivascular (PVAT). The depots were characterized morphologically, based on histology (number of CD68+ macrophages and crown like structures (CLS)), and functionally, based on adipokine and cytokine secretion measured by multiplex immune-assay. Differences between number of macrophages, CLS or secreted cytokines were compared using ANOVA. Linear and logistic regression analyses were used to assess the relation between depot-specific characteristics and clinical characteristics.
Results: SCAT macrophage infiltration, CLS or cytokine secretion profile did not relate to CVD risk factors. In all visceral depots the number of CLS was significantly related to insulin resistance, in contrast to the number of macrophages (Fig. 1A). In MAT we observed the strongest relation of both macrophage infiltration and CLS with the prevalence of the metabolic syndrome (OR 2.27; 95%CI 0.85, 6.03 and OR 1.53; 95%CI 0.86, 2.72 respectively). Functionally the AT depots differed as well, as OAT highly secreted MIF, MAT the highest levels of Leptin and PVAT secreted more RBP-4 (Fig 1B).
Conclusions: Different composition and function of distinct AT depots are related to presence of cardiometabolic risk factors in patients with abdominal aortic disease.
- © 2013 by American Heart Association, Inc.