Abstract 15778: The Association of Tamoxifen Use and Reduced Cardiovascular Events Among Asian Females With Breast Cancer
Background: Tamoxifen is used for breast cancer treatment and has been reported to be beneficial for cardiovascular system. It is unclear as to whether tamoxifen exhibits a favorable cardiovascular effect in Asian populations.
Methods and Results: From January, 1998 to December, 2006, a breast cancer cohort study was conducted using the Taiwan National Health Insurance database. Patients were divided according to whether tamoxifen was used. Study end points were occurrence of acute myocardial infarction (AMI), ischemic or hemorrhagic stroke and total cardiovascular events. A total of 3,690 female subjects were enrolled (mean age 50.1±11.3), 2,056 of whom received tamoxifen and 1,634 did not. During a mean follow-up of 6.9 years, tamoxifen group had significantly lower incidence of AMI (0.15% vs. 0.67%, p=0.008), ischemic stroke (1.99% vs. 3.30%, p=0.008), hemorrhagic stroke (0.15% vs. 0.55%, p=0.029), and total cardiovascular events(2.24% vs. 4.16%, p<0.001) than non-exposed group. After adjusting for comorbidities, tamoxifen was independently associated with reduced risk of myocardial infarction (hazard ratio [HR], 0.22; 95% confidence interval [CI], 0.07-0.70, ischemic stroke (HR, 0.52; 95% CI, 0.35-0.78), hemorrhagic stroke (HR, 0.25; 95% CI, 0.07-0.92), and total cardiovascular events (HR, 0.54; 95% CI, 0.37-0.78).
Conclusions: In Asian female breast cancer patients, tamoxifen use was associated with reduced risks of AMI, ischemic, hemorrhagic stroke and total cardiovascular event.
- © 2013 by American Heart Association, Inc.