Abstract 15757: Responsiveness of the Comprehensive Systemic Metabolite Profile To Weight Loss and Weight Gain in Healthy Young Adults
Introduction: Weight loss benefits the cardiovascular risk profile whilst weight gain is associated with increased cardiometabolic risk. The responsiveness of the comprehensive metabolite profile to spontaneous weight change among healthy young adults remains unknown. We characterized metabolic signatures of adiposity in young adults, and compared these signatures with the effects of weight change on the systemic metabolite profile.
Method: High-throughput magnetic resonance spectroscopy was employed to quantify 79 circulating metabolites in 1,488 young adults (range 24-39 years) from a population-based cohort in Finland. Metabolic signatures of elevated body mass index (BMI) were assessed cross-sectionally, and compared to longitudinal associations of weight change with changes in the metabolome during 6-year follow-up.
Results: Elevated BMI was associated with adverse alterations throughout the metabolite profile. The strongest assocations were observed for lipoprotein size and subclass distributions, fatty acid saturation and branched-chain amino acids. Widespead metabolite changes accompanied spontaneous weight change, and displayed an association pattern similar to cross-sectional signatures (R2=0.90). The longitudinal associations of 6-year weight change were stronger than anticipated based on cross sectional estimates (average 151±4%). A weight loss of 3-6% was paralleled by favorable changes throughout the systemic metabolite profile.
Conclusion: Increased adiposity within the normal weight range exhibited a sizeable impact throughout the metabolite profile in healthy young adults. Weight change was paralleled by global cardiometabolic changes, suggesting a broadly modifiable metabolic profile even through a modest weight loss.
- © 2013 by American Heart Association, Inc.