Abstract 15753: Lv Remodeling Caused by Persistent AF Was Associated With High Cardiac Hyaluronan in Cs Vein.
Background: Hyaluronan (HA) is a primary component of the extracellular matrix and is associated with several cardiovascular diseases. However, its exact cardiac origin and role in atrial fibrillation (AF) remain unclear. Therefore, we investigated the chamber-specific HA levels in patients with paroxysmal AF (PAF) and persistent AF (PSAF).
Methods: The levels of HA, a diacron-reactive oxygen metabolite (dROM) as a marker for oxidative stress; inflammatory cytokines, at different cardiac sites; and peripheral brain natriuretic peptide (BNP) and C-reactive protein (CRP) levels were measured in patients with PAF (n = 48) and PSAF (n = 34).
Results: Levels of HA in the coronary sinus (CS-HA) were significantly higher than those at other sites, both in PAF and PSAF patients; however, HA levels at sites other than the CS were similar and showed no intergroup differences. CS-HA in PSAF patients was significantly higher than those in PAF patients (32.7 ± 1.7 vs. 41.4 ± 2.6 pg/ml, p < 0.01). In oxidative stress, for all sites, dROM levels were higher in PSAF patients than in PAF patients; the levels were the highest in the coronary sinus at 429.5 ± 37.5 vs. 380.0 ± 30.6 Carratelli units p < 0.05). The CS-HA levels correlated positively with the dROM levels in the coronary sinus and the peripheral BNP levels in PSAF patients (r = 0.36, p < 0.05 and r = 0.572, p < 0.001, respectively), but not in PAF patients (r = -0.85, p = 0.566 and r = 0.121, p = 0.414, respectively). The PAF and PSAF groups did not differ in the site-specific levels of IL-6, TNF-α, and peripheral CRP, and both groups did not show any correlation between CS-HA and levels of these inflammatory markers.
Conclusions: Cardiac HA may either be a cause or consequence of AF, and cardiac HA levels correlated positively with cardiac oxidative stress and BNP levels in PSAF patients. These results indicate that cardiac HA may be associated with the persistence of AF. <!--EndFragment-->
- © 2013 by American Heart Association, Inc.