Abstract 15553: A Dietary Intervention Rich in Antioxidants Reduces Inflammation and Oxidative Stress
Background/Objectives: Inflammation and oxidative stress contribute to the pathophysiology of CVD. Antioxidants found in food products may slow the progression of CVD by inhibiting damaging inflammatory and oxidative processes. The purpose of this study was to test the effect of a dietary intervention rich in the antioxidant lycopene in persons at risk for CVD on biomarkers of inflammation and oxidative stress.
Subjects/Methods: Forty participants with multiple risk factors for CVD and baseline CRP levels greater than 5mg/dl were randomly assigned to one of two groups: an antioxidant dietary intervention and control. The intervention group received 29.4 mg of lycopene intake per day by drinking an 11.5 ounce serving of V8 100% low-sodium vegetable juice for 30 days. We obtained dietary intake levels from food frequency questionnaires and plasma for lycopene, C-reactive protein (CRP), and malondialhyde (MDA) at baseline and at end of the intervention (30 days). Paired sample and independent t-tests were used for data analysis.
Results: The sample was largely Caucasian, married and female, with a mean age of 50 years. The majority was obese and 57% self-reported having never smoked tobacco, while 25% were former smokers (greater than one year ago). Plasma lycopene levels increased in the intervention group over time compared to the control group (0.56 micromoles per liter [μmol/L] to 0.84μmol/L, p = 0.012; 0.59 μmol/L to 0.55 μmol/L). CRP levels decreased significantly in the intervention group over time (8.9 mg/dl to 6.3 mg/dl, p = 0.006) compared to the usual care group (9.5 mg/dl to 8.5 mg/dl). MDA levels decreased significantly in the intervention group over 30 days (1.93 mmol/L to 1.69 mmol/L, p = .047) compared to usual care group (1.56 mmol/L to 1.53mmol/L, p = .670).
Conclusions: These findings suggest the antioxidants in a 30 day dietary intervention of V8 juice decreased inflammation and oxidative stress levels in persons with multiple risk factors of CVD. These data provide support for a randomized controlled trial of dietary lycopene for the prevention of CVD.
- © 2013 by American Heart Association, Inc.